For the replacement of current HIV-1 medicines in adults who meet certain requirements. See Full Indication.
Hello, Undetectable you.
Meet JULUCA.
JULUCA is a once-daily, complete HIV-1
regimen that may help keep you undetectable* with
just 2 medicines in 1 small pill.†


*Undetectable means keeping the amount of HIV-1 in your blood at very low levels (less than 50 copies per mL).
†You must be undetectable for at least 6 months before starting JULUCA.
Taking JULUCA.
Understanding the "how" and "when" of taking JULUCA is important. Be sure to keep these considerations in mind:

Take JULUCA every day with a meal — exactly as your doctor tells you.
Taking JULUCA with a meal is important to help get the right amount of medicine in your body. A protein drink alone does not replace a meal.

Take JULUCA around the same time every day (or night).
Choose whatever time works best with your daily routine.

Take JULUCA as a replacement for your current HIV regimen.
JULUCA is a complete HIV-1 regimen, so it isn’t an addition to your current treatment, and it shouldn’t be taken with any other HIV-1 medicines.

Take JULUCA exactly as prescribed.
Do not miss a dose, change your dose, or stop taking JULUCA without talking to your doctor. Stay under a healthcare provider’s care when taking JULUCA.
Some prescription and over-the-counter medicines interact with JULUCA and need to be taken at a different time from when you take JULUCA. See the Risks & Side Effects page for more information.
Remember, it’s important to keep your overall health in mind when considering HIV treatment options. Your doctor is a good source of information. Be sure to talk with him or her if you have questions.
Clinical trials.


This study included 2 groups of patients, those who took JULUCA for 148 weeks and those who switched from their current stable regimen|| to JULUCA at week 52.
Patients who entered these studies were undetectable§ and on their current regimen for at least 6 months. They could not participate if they had liver problems, active hepatitis B, were likely to need treatment for hepatitis C during the trials, had failed a prior HIV treatment, or if they had suspected resistance to the components of JULUCA (dolutegravir or rilpivirine).
43 years was the median age of participants. |
28% of participants were at least 50 years of age. |
22% of participants were female. |
The results are in.

In these studies, most people stayed undetectable when they switched to JULUCA.¶
AT 48 WEEKS

1 pill with 2 medicines was as effective at keeping people undetectable¶ as their previous 3- or 4-drug regimens.||
95% of people who switched to JULUCA stayed undetectable§
95% of people who stayed on their current HIV regimen stayed undetectable§
AT 148 WEEKS
84% of people who took JULUCA from the beginning of the study stayed undetectable§
90% of people who switched to JULUCA at Week 52 stayed undetectable§
‡Both patients and their healthcare providers knew which medicines patients were taking.
§Undetectable means the amount of HIV-1 in the patients' blood was at very low levels (less than 50 copies per mL).
||Regimens contained 2 nucleoside reverse transcriptase inhibitors (NRTIs) plus either an integrase strand transfer inhibitor (INSTI), a non-nucleoside reverse transcriptase inhibitor (NNRTI), or a protease inhibitor (PI).
¶Your results may vary.
What can you expect?
You may experience some side effects when switching medications.
Here are the side effects reported in ≥2% of participants¶:
SWITCHED TO JULUCA AT THE START OF THE TRIALS
Taking JULUCA | ||
Common Side Effects |
Weeks 1-48 |
Weeks 1-148 |
---|---|---|
Diarrhea |
2% | 1% |
Headache |
2% | 2% |
Nausea |
1% | 2% |
Insomnia | <1% | 1% |
CONTINUED CURRENT HIV REGIMEN AT THE START OF THE TRIALS
Taking Current HIV Regimen |
Switched to JULUCA | |
Common Side Effects |
Weeks 1-48 |
Weeks 52-148 |
---|---|---|
Diarrhea |
<1% | 1% |
Headache | 0% | 2% |
Nausea | 0% | 1% |
Insomnia | <1% | 2% |
SWITCHED TO JULUCA AT THE START OF THE TRIALS
Taking JULUCA | ||
Discontinuation |
Weeks 1-48 |
Weeks 1-148 |
---|---|---|
People who left the study due to adverse events |
4% | 8% |
CONTINUED CURRENT HIV REGIMEN AT THE START OF THE TRIALS
Taking Current HIV Regimen |
Switched to JULUCA | |
Discontinuation |
Weeks 1-48 |
Weeks 52-148 |
---|---|---|
People who left the study due to adverse events |
<1% | 4% |
Of the people who took JULUCA from Week 1 and left the study due to adverse events, the most common type of adverse event leading to discontinuation was psychiatric disorders (3%).
¶Your results may vary.
I went through a lot to get to undetectable,
and reaching it was
one of the
greatest
achievements of my life.
Alex Undetectable since 2011

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