JULUCA is a prescription medicine that is used without other antiretroviral medicines to treat Human Immunodeficiency Virus-1 (HIV-1) infection in adults to replace their current anti-HIV-1 medicines when their healthcare provider determines that they meet certain requirements. HIV-1 is the virus that causes Acquired Immune Deficiency Syndrome (AIDS). It is not known if JULUCA is safe and effective in children.

Hello,
Undetectable*
you. This is
JULUCA.

Tiera
Undetectable
since 2010

*Undetectable means keeping
the amount of HIV-1 in the
blood at very low levels
(less than 50 copies per mL).

Tiera

JULUCA is the only once-daily, complete HIV-1 regimen that combines 2 medicines in just 1 small pill.

What's in other single-pill regimens?
While your current regimen may be a single pill, it could contain up to 4 medicines.

2 medicines. 1 pill.

dolutegravir

rilpivirine

Hello, Undetectable* you.
This is JULUCA.

*Undetectable means keeping the amount of HIV-1 in the blood at very low levels (less than 50 copies per mL).

Tiera
Undetectable
since 2010

Tiera

What's in other single-pill regimens?

While your current regimen may be a single pill, it could contain up to 4 medicines.

2 medicines. 1 pill.

dolutegravir

rilpivirine

JULUCA is the only once-daily,
complete HIV-1 regimen that combines

2 medicines in just 1 small pill.

2 things to know
about JULUCA:

  • 1.

    It may keep you undetectable
    with only 2 medicines in 1 pill.

  • 2.

    It’s 1 small pill, taken once per day with a mealin fact, it’s the smallest single-pill HIV-1 treatment available.

    pill Not actual pill size.

Undetectable means keeping the amount of HIV-1 in the blood at very low levels (less than 50 copies per mL). Your results may vary.

Pill size is not intended to convey efficacy, safety, or treatment adherence. Approximate pill size is 14 mm x 7 mm.

Information about JULUCA is available to take with you to your doctor's appointment. Just download this brochure.

brochure

Clinical trials.

JULUCA was:
Tested in
2 Open-label§ clinical trials
With more than
1,000 Undetectable|| adults
Through
48 Weeks

In these trials, patients either switched to JULUCA or continued their current HIV-1 regimen. Patients who entered these studies were undetectable|| and on their current regimen for at least six months. Patients could not participate if they had certain liver problems, active hepatitis B, or were likely to need treatment for hepatitis C during the trials. Patients were also not able to participate if they had failed a prior HIV treatment, or if they had suspected resistance to the components of JULUCA (dolutegravir or rilpivirine).

43 years

was the median
age of participants.

28%

of participants were at least 50 years of age.

22%

of participants
were female.

The results are in.
undetectable

In these studies, most people who were already undetectable|| for at least six months stayed undetectable when they switched to JULUCA for 48 weeks.#

1 pill with 2 medicines was as effective at keeping people undetectable|| as their previous 3- or 4-drug regimens.

95%

95% of people who switched to JULUCA stayed undetectable||

95% of people who stayed on their current HIV regimen stayed undetectable||

Your results may vary.

What can you expect?

You may experience some side effects when switching medications. Here’s what people who participated in the clinical trials reported:

Common Side Effects Switched to JULUCA Continued HIV Regimen
Diarrhea 2% <1%
Headache 2% 0%
Discontinuation Switched to JULUCA Continued HIV Regimen
People who left the study
due to side effects
4% <1%

Of the people who left the study due to side effects, the most common side effects leading to discontinuation were psychiatric disorders—2% of those patients taking JULUCA and <1% of those patients continuing their current HIV regimens.

Through 48 weeks, there was little or no difference between the groups studied in the following#:

  • Liver function
  • Kidney function
  • Cholesterol levels
  • Triglyceride levels

You should always talk to your doctor about any side effect.

§Both patients and their healthcare providers knew which medicines patients were taking.

||Undetectable means the amount of HIV-1 in the patients' blood was at very low levels (less than 50 copies per mL).

Regimens contained 2 nucleoside reverse transcriptase inhibitors (NRTIs) plus either an integrase strand transfer inhibitor (INSTI), a non-nucleoside reverse transcriptase inhibitor (NNRTI), or a protease inhibitor (PI).

#Your results may vary.

Taking JULUCA.

Understanding the "how" and "when" of taking JULUCA is important. Be sure to keep these considerations in mind:

  • Take JULUCA every day with a mealexactly as your doctor tells you. Taking JULUCA with a meal is important to help get the right amount of medicine in your body. A protein drink alone does not replace a meal.
  • Take JULUCA around the same time every day (or night). Choose whatever time works best with your daily routine.
  • Take JULUCA as a replacement for your current HIV regimen. JULUCA is a complete HIV-1 regimen, so it isn’t an addition to your current treatment, and it shouldn’t be taken with any other HIV-1 medicines.
  • Take JULUCA exactly as prescribed. Do not miss a dose, change your dose, or stop taking JULUCA without talking to your doctor. Stay under a healthcare provider’s care when taking JULUCA.

Milestones in
HIV treatment.

1987

The First Treatment

The first antiretroviral HIV treatment was approved in the US.

1996

Combination Treatments

Combination HIV medicines arrive, but may require multiple pills to be taken more than once a day.

2006

Once-Daily,
Single-Pill Regimens

People are able to reach undetectable with single-pill regimens, each containing 3 or 4 medicines.

2017

JULUCA

JULUCA helps people stay undetectable with 2 medicines in just 1 pill.

Undetectable means keeping the amount of HIV-1 in the blood at very low levels (less than 50 copies per mL). Your results may vary.

Elveth
Undetectable
since 2015

I learned how to get engaged in
my own care. I became wiser.
I asked questions. I found out
what worked best for me.

Tiera's Story See Elveth's story & others